Want to see Comment
Akira (movie) Because everyone has to see Akira at some point. Come one, it's freakin' Akira.
Azumanga Daioh (TV) Looking at the overwhelming presence of comedic serieses in my list, it boggles the mind as to why I haven't seen what is quite possibly the most well-known comedic series of all time.
Excel Saga (TV) Same as AzuDai. I'm amazed the kami of anime hasn't hit me with a bolt of lighting yet or something for not watching these two shows.
Grave of the Fireflies (movie)
Hidamari Sketch (TV)
Martian Successor Nadesico (TV)
Neon Genesis Evangelion (TV) It's like Akira except in series form; everyone has to see this at some point too.
Sayonara, Zetsubou-Sensei (TV)
Spirited Away (movie)
Sugar: A Little Snow Fairy (TV)
W~Wish (TV)