Most shoujo and josei shows are about relationships - these could be an established romantic relationship between two characters (i.e., Paradise Kiss, My Love Story), complex relationships among a group of people (i.e., Honey and Clover, Nana), or love triangles (or any other shape, i.e., Peach Girl). However, shoujo/josei is a broad genre and there are a handful of shows that don't quite fit the usual mold. Not only is Natsume's Book of Friends such a show, but the main character is male. It's also among the best shoujo on this list. There are also a few other oddball shows such as Jyu Oh Sei and X TV , the bloodiest and most violent shoujo on the list. If you have a soft spot for the genre (like me), and are looking for something to watch, pick a show. I recommend the majority of these shows. Enjoy!

Shoujo & Josei Rating
Aishiteruze Baby (TV) Good
Angel Sanctuary (OAV) Awful (dub), Not really good (sub)
Anonymous Noise (TV) Decent
Antique Bakery (TV) Very good
Blue Spring Ride (TV) Very good
Bokura ga Ita (TV) Very good
Boys Over Flowers (TV) Decent
Candy Candy (TV) Very good
Cardcaptor Sakura (TV) Good
Ceres, Celestial Legend (TV) Good
Chance Pop Session (TV) Decent
Chihayafuru (TV) Very good
Chihayafuru 2 (TV) Very good
(La) Corda D'Oro - primo passo (TV) Decent
D.N.Angel (TV) Decent
Dear Brother (TV) Very good
Diabolik Lovers (TV) Bad
Earl and Fairy (TV) Good
Fancy Lala (TV) Decent
Fruits Basket (TV) Excellent (dub & sub)
Full Moon o Sagashite (TV) Very good
Fushigi Yugi (TV) Good
Gakuen Alice (TV) Very good
Ghost Hunt (TV) Good
Glass Mask (TV 2/2005) Very good
Glass no Kamen (TV 1/1984) Very good
Hanasaku Iroha - Blossoms for Tomorrow (TV) Very good
Here Is Greenwood (OAV) Decent
His and Her Circumstances (TV) Good
Honey and Clover (TV) Decent
Honey and Clover II (TV) Good
Jyu-Oh-Sei (TV) Very good
Kaleido Star (TV) Good
Kaze to Ki no Uta SANCTUS -Sei naru kana- (OAV) Very good
Kimi ni Todoke - From Me to You (TV) Excellent
Kimi ni Todoke 2nd Season (TV) Very good
Kodocha (TV) Excellent
Legend of Basara (TV) Very good
Lovely Complex (TV) Very good
Magic Knight Rayearth (TV) Very good
Magic Knight Rayearth 2 (TV 2) Good
Maid Sama! (TV) Good
Maria Watches Over Us (TV) Decent
Marmalade Boy (TV) Very good
My Little Monster (TV) Very good
My Love Story!! (TV) Good
NANA (TV) Very good
Natsume Yūjin-Chō Go (TV 5) Very good
Natsume's Book of Friends (TV) Excellent
Natsume's Book of Friends (TV 2) Excellent
Natsume's Book of Friends (TV 3) Excellent
Natsume's Book of Friends (TV 4) Excellent
Natsuyuki Rendezvous (TV) Good
Nodame Cantabile (TV) Very good
Orange (TV) Good
Oshare Kozō wa Hanamaru (OAV) Weak
Ouran High School Host Club (TV) Very good
Paradise Kiss (TV) Very good
Peach Girl (TV) Good
Petite Princess Yucie (TV) Good
Please Save My Earth (OAV) Good
Pretear (TV) Decent
Princess Jellyfish (TV) Excellent
Princess Tutu (TV) Excellent
Revolutionary Girl Utena (TV) Good
(The) Rose of Versailles (TV) Masterpiece
S.A (TV) Decent
Sailor Moon (TV) Very good
Sailor Moon R (TV) Good
Sailor Moon S (TV) Good
Sailor Moon Sailor Stars (TV) Very good
Saint Tail (TV) Decent
Say "I love you." (TV) Good
Shōwa Genroku Rakugo Shinjū (TV) Very good
Skip Beat! (TV) Very good
Snow White with the Red Hair (TV) Very good
Snow White with the Red Hair (TV 2) Very good
(The) Story of Saiunkoku (TV) Very good
Ultra Maniac (TV) Decent
Vampire Knight (TV) Very good
Vampire Knight Guilty (TV) Very good
Wolf Girl & Black Prince (TV) Bad
(The) World Is Still Beautiful (TV) Good
X (TV) Very good
Yona of the Dawn (TV) Very good